Changing of antioxidant enzyme activity on the biliary obstructed rats treated with resveratrol


Cenesiz S., Yarim G. F. , Karabulut A. B. , Ara C.

DEUTSCHE TIERARZTLICHE WOCHENSCHRIFT, cilt.114, ss.345-348, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 114 Konu: 9
  • Basım Tarihi: 2007
  • Doi Numarası: 10.2377/0341-6593-114-345
  • Dergi Adı: DEUTSCHE TIERARZTLICHE WOCHENSCHRIFT
  • Sayfa Sayıları: ss.345-348

Özet

The aim of this study was to evaluate the role of antioxidant enzyme activity and nitric oxide levels induced by 28 day biliary obstruction in the rat. A total of 21 young Swiss albino rats were divided in to 3 groups. Bile duct ligations, bile duct ligations plus resveratrol, sham operated. Bile duct ligations plus resveratrol group received 10 mg/kg dose of resveratrol intraperitonealy once daily throughout for 28 days. Liver damage and cholestasis were determined by biochemical examination. SOD, CAT and GSH-PX activity decreased in BDL group compared with shame opareted groups (p < 0.001). NO levels increased in BDL groups compared with shame opareted groups (p < 0.001). SOD, CAT and GSH-PX activity was found higher in BDL+resveratrol treated groups than BDL groups (p < 0.001). In addition this NO levels decreased in BDL+resveratrol treated groups than BDL groups (p < 0.001). In conclusion, it is thought that resveratrol may be used as a protective agent in biliary obstructions; however, further clinical and experimental studies are needed to verify its antioxidative and hepatoprotective effects.