Synthesis, structural and thermal characterizations and in vitro cytotoxic activities of new cyclotriphosphazene derivatives

KORAN K., TEKİN Ç., Caliskan E., TEKİN S., SANDAL S., GÖRGÜLÜ A. O.

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, cilt.192, sa.9, ss.1002-1011, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 192 Sayı: 9
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1080/10426507.2017.1315420
  • Dergi Adı: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1002-1011
  • Anahtar Kelimeler: Cyclotriphosphazene, cytotoxic activities, chalcone-phosphazene, cancer cell lines, ANTIMICROBIAL ACTIVITIES, ANTICANCER ACTIVITIES, CHALCONE DERIVATIVES, DNA INTERACTIONS, BIS-CHALCONE, COMPLEXES, AGENTS, FLUORESCENCE, BLUE, DENDRIMERS
  • İnönü Üniversitesi Adresli: Evet

Özet

We investigated the cytotoxic effects of the newly synthesized cyclotriphosphazene derivatives on A2780 (ovarian), PC-3 and LNCaP (prostate) cancer cell lines. 4'-hydroxy-substituted-chalcone compounds (2-8) were reacted with diphenyl-cyclotriphosphazene (DPP) in the presence of acetone/K2CO3 in order to obtain novel cyclotriphosphazene compounds (DPP 2-8). The structures of DPP2-8 were characterized by MALDI-TOF mass spectrometry, FT-IR, elemental analysis, H-1, C-13-APT, and P-31 NMR measurements. The thermal properties of all phosphazene compounds have been studied after synthesis and characterization procedure. The cytotoxic effects of DPP 2-8 were examined primarily by applying the MTT method based on the measurement of mitochondrial activity. In this regard, several phosphazene compounds have shown high chemotherapeutic effect at low dose (p < 0.05). When the cytotoxic effects of DPP 2-8 at doses of 1, 5, 25, 50 and 100 mu M on A2780 cells were examined, it was observed that DPP-3, DPP-4, DPP-5 and DPP-7 were more effective than other derivatives suggested by their high Log IC50 values (p < 0.05). The compounds DPP 2-8 possess cytotoxic activity against PC-3 and LNCaP cells (especially compounds DPP-4 and DPP-5, p < 0.05).