LoC SENSOR ARRAY PLATFORM FOR REAL-TIME COAGULATION MEASUREMENTS


Cakmak O., Kilinc N. , Ermek E., Mostafazadeh A., Elbuken C., Yaralioglu G. G. , ...Daha Fazla

27th IEEE International Conference on Micro Electro Mechanical Systems (MEMS), San-Francisco, Kostarika, 26 - 30 Ocak 2014, ss.330-333 identifier identifier

  • Cilt numarası:
  • Doi Numarası: 10.1109/memsys.2014.6765643
  • Basıldığı Şehir: San-Francisco
  • Basıldığı Ülke: Kostarika
  • Sayfa Sayıları: ss.330-333

Özet

This paper reports a MEMS-based sensor array enabling multiple clot-time tests in one disposable microfluidic cartridge using plasma. The versatile LoC (Lab-on-Chip) platform technology is demonstrated here for real-time coagulation tests (activated Partial Thrompoblastin Time (aPTT) and Prothrombin Time (PT)). The system has a reader unit and a disposable cartridge. The reader has no electrical connections to the cartridge, which consists of multiple microfluidic channels and MEMS microcantilevers placed in each channel. Microcantilevers are made of electro-plated nickel and actuated remotely using an external electro-coil. The read-out is also conducted remotely by a laser and the phase of the MEMS oscillator is monitored real-time. The system is capable of monitoring coagulation time with a precision estimated at 0.1sec.