LoC SENSOR ARRAY PLATFORM FOR REAL-TIME COAGULATION MEASUREMENTS
27th IEEE International Conference on Micro Electro Mechanical Systems (MEMS), San-Francisco, Kostarika, 26 - 30 Ocak 2014, ss.330-333, (Tam Metin Bildiri)
- Yayın Türü: Bildiri / Tam Metin Bildiri
- Cilt numarası:
- Doi Numarası: 10.1109/memsys.2014.6765643
- Basıldığı Şehir: San-Francisco
- Basıldığı Ülke: Kostarika
- Sayfa Sayıları: ss.330-333
- İnönü Üniversitesi Adresli: Hayır
Özet
This paper reports a MEMS-based sensor array enabling multiple clot-time tests in one disposable microfluidic cartridge using plasma. The versatile LoC (Lab-on-Chip) platform technology is demonstrated here for real-time coagulation tests (activated Partial Thrompoblastin Time (aPTT) and Prothrombin Time (PT)). The system has a reader unit and a disposable cartridge. The reader has no electrical connections to the cartridge, which consists of multiple microfluidic channels and MEMS microcantilevers placed in each channel. Microcantilevers are made of electro-plated nickel and actuated remotely using an external electro-coil. The read-out is also conducted remotely by a laser and the phase of the MEMS oscillator is monitored real-time. The system is capable of monitoring coagulation time with a precision estimated at 0.1sec.