Akademik Veri Yönetim Sistemi
ACTA PHYSIOLOGICA, cilt.221, ss.53, 2017 (SCI-Expanded)
AIM: The addition of desired functional groups to the
periphery of organocyclophosphazene rings changes
its biological and physical properties and enables them
to be used in different areas. Both chalcone and
phosphazene derivatives are biologically active
compounds. Therefore, we aimed to examine the
anticancer properties of full substituted chalconecylophosphazene compounds resulting from the
reaction of these biologically active compounds.
METHODS: In the present study, full substituted
organocyclotriphosphazene compounds bearing
chalcone groups (the code in this article of compounds
3,7, 8, 9 and 11) were synthesized as defined by Koran
et al [1]. And then In vitro cytotoxic activities of these
chalcone-phosphazene derivatives were determined by
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium
bromide (MTT) assay. Cytotoxic activity of full
substituted chalcone-cyclotriphosphazene analogues
against on human ovarian (A2780) and breast (MCF7) cancer cell lines was investigated.. Statistical
analysis of the data was performed by the Bonferroni
correction Mann Whitney U test in IBM SPSS
Statistics 24.0 Windows package program. The value
p<0.05 was accepted as statistically significant.
RESULTS: Different doses (1, 5, 25, 50 and 100 μM)
of all the compound (3,7, 8, 9 and 11) was treated with
A2780 and MCF-7 for 24 h. All doses of compound
reduced cell viability of A2780 cells (p <0.05).
CONCLUSION: These compounds (1, 2 and 3)
displayed potential cytotoxic activity towards on
MCF-7 and A2780 cancer cells.