Transfusion-associated graft-versus-host disease in patients with and without immunodeficiency: Report of six cases

Aydogdu I., KAYA E. , Karadag N. , Erkurt M. A. , Kuku I. , Ozhan O., ...Daha Fazla

TRANSFUSION MEDICINE AND HEMOTHERAPY, cilt.34, ss.79-82, 2007 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 34 Konu: 1
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1159/000098105
  • Sayfa Sayıları: ss.79-82


Background: Transfusion-associated graft-versus-host disease (TA-GVHD) is extremely rare compared to transplant-associated GVHD. Mortality in TA-GVHD approaches to 100%. We report six cases with TA-GVHD that were seen during 1994-2004 and discuss the clinical characteristics. Case Reports: Two patients were immunosuppressed, and 4 patients were immunocompetent. All 6 patients were transfused with non-irradiated blood products from relatives before TA-GVHD had occurred. Diagnosis of TA-GVHD in all patients was made based on characteristic clinical manifestations and laboratory findings. All patients died due to TA-GVHD-related complications such as progressive pancytopenia and liver dysfunctions. Conclusion: Our data shows that TA-GVHD is a serious complication of transfusion of blood products among relatives.