Protective effects of dexpanthenol in an experimental model of necrotizing enterocolitis

KARADAĞ A., ÖZDEMİR R., KURT A., PARLAKPINAR H., POLAT A., VARDI N., ...Daha Fazla

JOURNAL OF PEDIATRIC SURGERY, cilt.50, sa.7, ss.1119-1124, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 7
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.jpedsurg.2014.10.053
  • Dergi Adı: JOURNAL OF PEDIATRIC SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1119-1124
  • Anahtar Kelimeler: Necrotizing enterocolitis, Dexpanthenol, Pantothenic acid, Antioxidant, Reactive oxygen species, NEONATAL-RAT MODEL, NECROSIS-FACTOR-ALPHA, ASCITES TUMOR-CELLS, PANTOTHENIC-ACID, OXIDATIVE STRESS, LIPID-PEROXIDATION, FREE-RADICALS, APOPTOSIS, INJURY, GLUTATHIONE
  • İnönü Üniversitesi Adresli: Evet

Özet

Background/purpose: In pathogenesis of necrotizing enterocolitis (NEC), both oxidative stress and inflammation are considerable risk factors. The study was designed to evaluate whether administration of dexpanthenol (Dxp) is able to attenuate intestinal injury through the antioxidant and antiinflammatory mechanisms in a neonatal rat model of NEC.