Synthesis and Antimicrobial Activities of Some Transition Metal Benzimidazole Complexes

KÜÇÜKBAY H., GÜNAL S., Orhan E., Durmaz R.

ASIAN JOURNAL OF CHEMISTRY, cilt.22, sa.9, ss.7376-7382, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 9
  • Basım Tarihi: 2010
  • Dergi Adı: ASIAN JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.7376-7382
  • Anahtar Kelimeler: Benzimidazole derivatives, Benzimidazole metal complexes, Antibacterial activity, Antifungal activity, IMIDAZOLE DERIVATIVES, ANTIFUNGAL ACTIVITIES, ANTIBACTERIAL, BENZOTHIAZOLE, ZN(II), LIGAND
  • İnönü Üniversitesi Adresli: Evet

Özet

The interaction of N-monosubstituted benzimidazoles with various metal salts [CoCl(2), NiCl(2) and Zn(OAc)(2))] were yielded stable solid metal benzimidazole complexes. All the metal complexes were identified by (1)H NMR, FT-IR spectroscopic techniques, elemental analysis and screened for their in vitro antimicrobial activities against the standard strains: Enterococcus faecal's (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853) and yeasts Candida albicans and Candida tropicalis Some of the compounds inhibited the growth of gram-positive bacteria (E. faecalis and S aureus) at MIC values between 200 and 800 mu g/mL. None of the compounds exhibit antimicrobial activity against gram-negative bacteria (E. coli and P aeruginosa) at the concentrations studied (6.25-800 mu g/mL). Some of the tested compounds exhibit an antifungal activity with a range of the MICs between 100 and 800 mu g/mL.