Effect of water extract of Turkish propolis on tuberculosis infection in guinea-pigs

Yildirim Z., Hacievliyagil S., Kutlu N., Aydin N., Kurkcuoglu M., Iraz M., ...Daha Fazla

PHARMACOLOGICAL RESEARCH, cilt.49, ss.287-292, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 49 Konu: 3
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/j.phrs.2003.10.007
  • Sayfa Sayıları: ss.287-292


Mycobacterium tuberculosis (H37Rv)-infected guinea-pig model was used to investigate the effect of water extract of propolis (WEP). After subcutaneous inoculation of tubercle bacilli, each animal received oral WEP (n = 9), isoniazid (n = 5) or saline (n = 6) as placebo and were sacrificed 30 days later. Formation of necrosis was less prominent in the group treated with WEP, but was not statistically significant (P > 0.05). The granuloma formation in the same group was more prominent than the placebo and isoniazid groups; however, this finding failed to reach statistical significance by the Kruskal-Wallis test (P > 0.05). These findings suggest that Turkish WEP may have a limited effect on the development of tuberculosis infection in this guinea-pig model. (C) 2003 Elsevier Ltd. All rights reserved.