Lack of association between TNF alpha gene polymorphism at position-308 and risk of acute rheumatic fever in Turkish patients

Berdeli A., TABEL Y., Celik H., Ozyurek R., Dogrusoz B., AYDIN H. H.

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, cilt.35, sa.1, ss.44-47, 2006 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 1
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1080/03009740510026760
  • Dergi Adı: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.44-47
  • İnönü Üniversitesi Adresli: Evet

Özet

Objective: Acute rheumatic fever (ARF) is a multisystem inflammatory disease process that follows nasopharyngeal infection caused by group A streptococcus ( GAS) ( Streptococcus pyogenes). Recent studies have demonstrated that allelic variations at the tumour necrosis factor alpha (TNF alpha) locus are involved in the nature of rheumatic diseases such as juvenile idiopathic arthritis and rheumatic heart disease. Thus, TNF alpha polymorphisms at - 308 in ARF patients might be useful in contributing to identification of the primary factors associated with pathogenesis of ARF.