Lack of association between catechol-O-methyltransferase and schizophrenia in a Turkish population

ACAR, CEREN; SÖZEN, MUSTAFA; GOZUKARA, HARİKA; ORMAN, Kubra; KARTALCI, ŞÜKRÜ

doi:10.1515/tjb-2015-0002

Lack of association between catechol-O-methyltransferase and schizophrenia in a Turkish population

Atıf İçin Kopyala

ACAR C., SÖZEN M. M., GOZUKARA H., ORMAN K., KARTALCI Ş.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.40, sa.3, ss.205-209, 2015 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 40 Sayı: 3
Basım Tarihi: 2015
Doi Numarası: 10.1515/tjb-2015-0002
Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.205-209
İnönü Üniversitesi Adresli: Evet

Özet

Objective: Catechol-O-methyltransferase (COMT) is the key molecule in the catabolism of catecholamines like dopamine which is an important molecule in schizophrenia. Due to its function and location COMT gene is a strong candidate gene for schizophrenia. The aim of this study was to investigate the possible associations of 3 COMT single nucleotide polymorphisms (SNPs) and schizophrenia in our population. COMT enzyme activity is regulated by a widely known Val158Met polymorphism (rs4680), along with the variation of the SNPs rs737865 and rs165599.