Effects of caffeic acid phenethyl ester and epidermal growth factor on the development of caustic esophageal stricture in rats


Koltuksuz U., Mutus H., Kutlu R., Ozyurt H., Cetin S., Karaman A., ...Daha Fazla

JOURNAL OF PEDIATRIC SURGERY, cilt.36, ss.1504-1509, 2001 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 36 Konu: 10
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1053/jpsu.2001.27032
  • Dergi Adı: JOURNAL OF PEDIATRIC SURGERY
  • Sayfa Sayıları: ss.1504-1509

Özet

Background/Purpose: An experimental study was performed to modify the healing response in caustic esophageal burns to prevent stricture development. Two different agents with different modes of actions, caffeic acid phenethyl ester (CAPE) and epidermal growth factor (EGF), were studied. CAPE has antiinflammatory, immunomodulatory, antioxidant, and antimitotic properties. EGF has known properties in supporting wound healing and in protecting esophagus from injuries.