Thymoquinone protection against 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin induced nephrotoxicity in rats

ERDEMLİ M. E. , Yigitcan B., Erdemli Z., GÜL M. , GÖZÜKARA BAĞ H. G. , GÜL S.

BIOTECHNIC & HISTOCHEMISTRY, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume:
  • Publication Date: 2020
  • Doi Number: 10.1080/10520295.2020.1735520
  • Keywords: kidney, nephrotoxicity, oxidative stress, 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin, thymoquinone, TOTAL ANTIOXIDANT CAPACITY, NIGELLA-SATIVA SEEDS, DIBENZO-P-DIOXINS, OXIDATIVE STRESS, AH RECEPTOR, VITAMIN-E, TOXICITY, TISSUES, DAMAGE, TCDD


We investigated the effects of thymoquinone (TQ) on kidney tissues of Wistar rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced nephrotoxicity. We used 50 rats divided into five groups; control, corn oil, TCDD, TQ, TCDD + TQ. We found that malondialdehyde (MDA), total oxidant status (TOS), blood urea nitrogen (BUN), creatinine, interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) levels in the TCDD treated group increased significantly compared to the other groups, while reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and total antioxidant status (TAS) levels decreased in the TCDD group. In the TQ treated group, we found that GSH, SOD, CAT, TAS levels increased and MDA, TOS, IL-6 and TNF-alpha levels decreased compared to the other groups. The effects of TCDD on oxidative stress parameters, inflammatory markers and histological changes were ameliorated by TQ treatment.