Effects of iloprost on bleomycin-induced pulmonary fibrosis in rats compared with methyl-prednisolone.

AYTEMUR Z. A., HACIEVLİYAGİL S. S., Iraz M., Samdanci E., Ozerol E., Kuku I., ...Daha Fazla

Revista portuguesa de pneumologia, cilt.18, sa.6, ss.272-7, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 6
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.rppneu.2012.04.010
  • Dergi Adı: Revista portuguesa de pneumologia
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.272-7
  • Anahtar Kelimeler: Pulmonary fibrosis, Bleomycin, Iloprost, Methyl-prednisolone, Rats, LUNG FIBROSIS, PROSTACYCLIN, COLCHICINE, MICE
  • İnönü Üniversitesi Adresli: Evet

Özet

Objective: Prostacyclin (PGI2) has been shown to inhibit the expression of pro-inflammatory and pro-fibrotic mediators in pulmonary fibrosis. In this study, we aimed to test the preventive effects of intraperitoneally administered iloprost, a stable PGI2 analog, on bleomycin-induced pulmonary fibrosis in rats and to compare the effects of iloprost with the effects of methylprednisolone, a traditional therapy.