Effects of iloprost on bleomycin-induced pulmonary fibrosis in rats compared with methyl-prednisolone

AYTEMUR, ZEYNEP; HACIEVLİYAGİL, SÜLEYMAN; Iraz, M.; Samdanci, E.; Ozerol, E.; Kuku, I.; Nurkabulov, Z.; Yildiz, K.

doi:10.1016/j.rppneu.2012.04.010

Effects of iloprost on bleomycin-induced pulmonary fibrosis in rats compared with methyl-prednisolone

Atıf İçin Kopyala

AYTEMUR Z. A. , HACIEVLİYAGİL S. S. , Iraz M., Samdanci E., Ozerol E., Kuku I., ...Daha Fazla

REVISTA PORTUGUESA DE PNEUMOLOGIA, cilt.18, ss.272-277, 2012 (SCI İndekslerine Giren Dergi)

Cilt numarası: 18 Konu: 6
Basım Tarihi: 2012
Doi Numarası: 10.1016/j.rppneu.2012.04.010
Dergi Adı: REVISTA PORTUGUESA DE PNEUMOLOGIA
Sayfa Sayıları: ss.272-277

Özet

Objective: Prostacyclin (PGI2) has been shown to inhibit the expression of pro-inflammatory and pro-fibrotic mediators in pulmonary fibrosis. In this study, we aimed to test the preventive effects of intraperitoneally administered iloprost, a stable PGI2 analog, on bleomycin-induced pulmonary fibrosis in rats and to compare the effects of iloprost with the effects of methylprednisolone, a traditional therapy.