Erdosteine prevents doxorubicin-induced cardiotoxicity in rats


Yagmurca M., Fadillioglu E., Erdogan H., Ucar M., Sogut S., Irmak M.

PHARMACOLOGICAL RESEARCH, cilt.48, ss.377-382, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 48 Konu: 4
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1016/s1043-6618(03)00185-3
  • Dergi Adı: PHARMACOLOGICAL RESEARCH
  • Sayfa Sayıları: ss.377-382

Özet

The clinical use of doxorubicin (Dxr) is limited by its cardiotoxic effects which are mediated by oxygen radicals. The purpose of this study was to investigate in vivo protective effects of erdosteine, an antioxidant agent because of its secondary active metabolites in vivo, against the cardiotoxicity induced by Dxr in rats.