Erdosteine prevents doxorubicin-induced cardiotoxicity in rats

Yagmurca M., Fadillioglu E., Erdogan H., Ucar M., Sogut S., Irmak M.

PHARMACOLOGICAL RESEARCH, cilt.48, sa.4, ss.377-382, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Sayı: 4
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1016/s1043-6618(03)00185-3
  • Dergi Adı: PHARMACOLOGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.377-382
  • İnönü Üniversitesi Adresli: Hayır

Özet

The clinical use of doxorubicin (Dxr) is limited by its cardiotoxic effects which are mediated by oxygen radicals. The purpose of this study was to investigate in vivo protective effects of erdosteine, an antioxidant agent because of its secondary active metabolites in vivo, against the cardiotoxicity induced by Dxr in rats.