Determination of gentamicin by using square wave anodic stripping voltammetry with poly (β‑cyclodextrin‑p‑toluene sulfonic acid) modified glassy carbon electrode

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Burç M., Titretir Duran S., Güngör Ö., Karagözler A. E.

POLYMER BULLETIN, cilt.1, ss.1-23, 2023 (SCI-Expanded)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s00289-023-05011-0
  • Dergi Adı: POLYMER BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Chemical Abstracts Core, Chimica, Compendex, INSPEC
  • Sayfa Sayıları: ss.1-23
  • İnönü Üniversitesi Adresli: Evet

Özet

Abstract

In this study, an effective electrochemical method based on modified glassy carbon electrode was developed for the determination of gentamicin. Firstly, the poly β-cyclodextrin-p-toluene sulfonic acid/glassy carbon electrode as gentamicin selective electrode was prepared by electropolymerization technique. In situ electropolymerization of β-cyclodextrin and p-toluene sulfonic acid was conducted on bare glassy carbon electrode by controlled potential cycling. Characterization of the prepared poly β-cyclodextrin-p-toluene sulfonic acid/glassy carbon electrode was performed using cyclic voltammetry and electrochemical impedance spectroscopy. Then, the effects of various parameters were investigated using square wave anodic stripping voltammetry in citrate buffer containing 4.0 mmol L−1 gentamicin. The calibration graph plotted over the range of 0.06–4.0 mmol L−1 gentamicin concentration showed high linearity. Correlation coefficient, detection limit and quantitation limit were obtained from the calibration graph as 0.9999, 3.7 μmol L−1 and 12.4 μmol L−1, respectively. According to these results, it is seen that the prepared poly β-cyclodextrin-p-toluene sulfonic acid/glassy carbon electrode can be successfully used for the determination of in many pharmacological, medical and biochemical applications.