Akademik Veri Yönetim Sistemi
Electrochimica Acta, cilt.536, 2025 (SCI-Expanded)
A novel electrochemical sensor based on a NiZn/Co heterostructure embedded in nitrogen-doped porous carbon (NiZn/Co@NPC) was successfully developed for the sensitive determination of Acalabrutinib (ACA). The NiZn/Co@NPC nanocomposite was synthesized using Ni/Zn@ZIF as a precursor, ensuring the uniform dispersion of nanoparticles within the porous carbon matrix, as confirmed by XRD, SEM, and TEM analyses. The incorporation of multi-metallic active sites and the high surface area of the porous carbon significantly enhanced electron transfer, minimized nanoparticle aggregation, and improved electrochemical performance. The NiZn/Co@NPC-modified glassy carbon electrode (NiZn/Co@NPC/GCE) exhibited superior sensitivity compared to the bare electrode, with a wide linear detection range (0.5–5.0 µM), a low detection limit (0.03 µM), and excellent repeatability (RSD = 1.4 %) and reproducibility (RSD = 2.0 %). The sensor demonstrated high selectivity against potential interferents, confirming its robustness for real-world applications. Analytical validation in pharmaceutical capsules, spiked urine, and plasma samples using the standard addition method yielded recoveries ranging from 99.4 % to 101.9 %, confirming the accuracy and reliability of the electrochemical method. The incorporation of multi-metallic active sites and creation of more electroactive surface area in the porous carbon by doping different redox active metals leads to significantly enhanced charge transfer, minimized nanoparticle aggregation, and improved electrochemical performance.