Clinical Review of 95 Patients with 46,XX Disorders of Sex Development Based on the New Chicago Classification

Ocal G., Berberoglu M., Siklar Z., Aycan Z., Hacihamdioglu B., Erdeve S. S., ...More

JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY, vol.28, no.1, pp.6-11, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 28 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.1016/j.jpag.2014.01.106
  • Journal Name: JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.6-11
  • Keywords: Disorders of sex development, 46,XX karyotype, Etiology, P450 OXIDOREDUCTASE DEFICIENCY, CONSENSUS STATEMENT, MANAGEMENT, DIFFERENTIATION, EXPERIENCE, MUTATIONS, INTERSEX, DSD
  • Inonu University Affiliated: Yes

Abstract

Study Objective: The aim of our study was to determine the etiologic distribution of 46,XX disorder of sexual development (DSD) according to the new DSD classification system and to evaluate the clinical features of this DSD subgroup in our patient cohort. Participants: The evaluation criteria and clinical findings of 95 46,70C patients were described by clinical presentation, gonadal morphology, genital anatomy, associated dysmorphic features, presence during prenatal period with/without postnatal virilization, hormonal characteristics, and presence or absence of steroidogenic defects among 319 patients with DSD.