In this study, the molten salt-heavy metal mixtures 99-95% Li20Sn80-1-5% SFG-Pu, 99-95% Li20Sn80-1-5% SFG-PuF4, 99-95% Li20Sn80-1-5% SFG-PuO2 were used as fluids. The fluids were used in the liquid first-wall, blanket and shield zones of the designed hybrid reactor system. 9Cr2WVTa ferritic steel with the width of 4 cm was used as the structural material. The parameters of radiation damage are proton, deuterium, tritium, He-3 and He-4 gas production rates. In this study, the effects of the selected fluid on the radiation damage, in terms of individual as well as total isotopes in the structural material, were investigated for 30 full power years (FPYs). Three-dimensional analyses were performed using the most recent version of the MCNPX-2.7.0 Monte Carlo radiation transport code and the ENDF/B-VII.0 nuclear data library. Published by Elsevier Ltd.