Brain MR spectroscopy findings in neonates with hypothyroidism born to mothers living in iodine-deficient areas

Akinci A., Sarac K., Gungor S., Mungan I., Aydin O.

AMERICAN JOURNAL OF NEURORADIOLOGY, vol.27, no.10, pp.2083-2087, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 10
  • Publication Date: 2006
  • Journal Name: AMERICAN JOURNAL OF NEURORADIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2083-2087
  • Inonu University Affiliated: No

Abstract

BACKGROUND AND PURPOSE: Iodine deficiency and hypothyroxinemia have a negative effect on the development of the central nervous system during fetal and early postnatal life. MR spectroscopy is a sensitive technique for detecting the changes of brain metabolites in various neurodevelopmental disorders. By using MR spectroscopy, we aimed to show the decrease in N-acetylaspartate (NAA) levels in neonates with hypothyroidism who were born in iodine-deficient areas and its normalization with early thyroxine therapy.