Akademik Veri Yönetim Sistemi
BIOTECHNIC AND HISTOCHEMISTRY, cilt.98, sa.3, ss.157-165, 2022 (SCI-Expanded)
Primary or metastatic hepatic malignancies are common. Partial hepatectomy (PH) is the primarytreatment for both benign and malignant hepatic neoplasms; it also is used for living donor livertransplantation. The regenerative potential of the liver after PH is 70–80% in humans. Weinvestigated the protective and therapeutic effects of agomelatine (AGM) on rat liverregeneration following PH. We used 32 rats distributed equally into four groups: group 1, shamcontrol; group 2, PH group; group 3, administered 20 mg/kg AGM orally once/day for 7 daysfollowing PH; group 4, administered 20 mg/kg AGM orally once/day 3 days before and 7 daysfollowing PH for 10 days. Liver samples were analyzed for antioxidants and free radicals. Tissuesamples were processed and stained with hematoxylin and eosin to assess histopathologicalstatus and stained immunohistochemically for Ki-67. We found that PH reduced antioxidantenzymes and increased tissue reactive oxygen species, whereas AGM treatment had theopposite effect on these parameters. Our biochemical and histopathological findings wereconsistent. PH caused sinusoid congestion and dilation. Intensity of Ki-67 immunostaining ofhepatocytes was increased in group 2, whereas these were reduced in group 4. Intensity of Ki-67immunostaining of hepatocytes was increased in group 2, whereas it was reduced in the group 4compared to group 1. We found that AGM was hepatoprotective following PH due to itsantioxidant and free radical scavenger properties.