Attenuation of ureteral obstruction-induced renal injury by polyenylphosphatidylcholine.

AKIN M., DEMİRBİLEK S., Ay S., Gurunluoglu K., Turkmen E., TAS E., ...More

International journal of urology : official journal of the Japanese Urological Association, vol.14, no.4, pp.350-6, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 4
  • Publication Date: 2007
  • Doi Number: 10.1111/j.1442-2042.2006.01717.x
  • Journal Name: International journal of urology : official journal of the Japanese Urological Association
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.350-6
  • Keywords: alpha smooth muscle actin, nuclear factor kappa beta, polyenylphosphatidylcholine, transforming growth factor-beta1, unilateral ureteral obstruction, GROWTH-FACTOR-BETA, NF-KAPPA-B, POLYUNSATURATED PHOSPHATIDYLCHOLINE, OXIDATIVE STRESS, ALPHA-TOCOPHEROL, NEPHROPATHY, KIDNEY, RATS, DILINOLEOYLPHOSPHATIDYLCHOLINE, CONSEQUENCES
  • Inonu University Affiliated: Yes

Abstract

Background: The cytoprotective, antioxidant and antifibrotic effects of polyenylphosphatidylcholine (lecithin, PPC) have been demonstrated both experimentally and clinically. The present study investigated whether PPC treatment has any beneficial effect on renal injury in unilateral partial ureteral obstruction (UUO) in rats.