Synthesis of some new pyridylethylated benzoxa(thia)zolinones with analgesic activitiy


Gokhan N., Aktay G., Erdogan H.

TURKISH JOURNAL OF CHEMISTRY, cilt.28, ss.123-132, 2004 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 28 Konu: 1
  • Basım Tarihi: 2004
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Sayfa Sayıları: ss.123-132

Özet

Eighteen new 3-[2-(2-/4-pyridyl)ethyl]benzoxlinone(benzothiazolinone) derivatives were synthesized by reacting 2-/4-vinylpyridine and appropriate benzoxazolinones and benzothiazolinones. The analgsic activities of these compounds were investigated by modified Koster and hot-plate tests. Test results revealed that most of the compounds at 100 mg/kg dose levels have higher analgestic activities than acetylisalicylic acid. Compounds with bromo substituents on the phenyl ring in the 6-position of the main ring seemed to show less activity than those with fluorinated ones. Compound 6b showed remarkably high activity in the hot-plate test, although it was inactive in the Koster test. However compound 3a had statistically significant high peripheral analgesic activity at all doses compared to other compounds, although it was inactive in the hot-plate test.