Akademik Veri Yönetim Sistemi
PROGRESS IN NUTRITION, cilt.25, sa.2, ss.1-13, 2023 (SCI-Expanded)
Background: Recently, some new generation therapeutic
applications that can be used as an alter-native to
routine pharmacological agents
in the treatment
of ulcerative colitis
(UC) have emerged.
These applications are
using of probiotics, prebiotics, synbiotics, and fecal microbiota
transplantation. Objective: In this review, these
therapeutic applications, which have the potential to be used as an alternative
to pharmaco-logical agents in the treatment of UC will be
investigated. Results: Probiotic
supplements are aimed increasing the number of
beneficial bacteria in the intestinal microbiota composition, prebiotic
supplements support the development of probiotics, and synbiotic
supplements combine the positive metabolic effects of both prebi-otic and probiotic
supplements. Fecal microbiota transplantation (FMT) is used to correct
dysbiosis in UC. In studies in the literature, we observed that
all these applications generally mediate the improvement of the clinical remission
levels of patients with UC, strengthening of the intestinal barrier mechanism,
changing of the metabolic parameters of the inflammation
picture positively, and the attainment of a healthier composi-tion of the
intestinal microflora. Conclusions: Alternative
therapeutic applications used in the treatment of UC have been shown to
have positive metabolic results on the clinical course of the disease. However,
because there is no scientific consensus on the form,
duration and content of such applications, further comprehensive studies should be
conducted on the subject. Thus, the potential of using probiotic, prebiotic,
synbiotic supple-ments and FMT as an alternative therapeutic
application in the treatment of UC will be revealed more clearly.