FRESENIUS ENVIRONMENTAL BULLETIN, cilt.16, sa.6, ss.596-600, 2007 (SCI-Expanded)
Organic and inorganic selenium compounds are essential for humans and animals in reduction of oxidative stress. In the present study, the protective effects of novel synthetic organoselenium compounds (Se I and Se II) against DMBA-induced rats were compared in hematological parameters. A statistically significant increase (P < 0.05) in total leukocyte count (WBC), as well as eosinophils, neutrophils, and monocyte values for rats exposed to DMBA was found. However, there was a statistically significant decrease in lymphocyte value (P < 0.05), and also in erythrocyte, hemoglobin and hematocrit values for rats exposed to DMBA, but MCV and MCH values (P < 0.05) significantly increased. With administration of novel synthetic organoselenium compounds (Se I and Se II), the effects of toxic DMBA on erythrocyte, hemoglobin and hematocrit values could be prevented statistically significant (P < 0.05). DMBA-induction in rats' hematological parameters was investigated, and the effects of Se I and Se II were outlined, evidencing their preservation role on hematological parameters and against DMBA toxicity.