Interferon-alpha reduces the development of experimental necrotizing enterocolitis

Uguralp S., Mizrak B., Karabulut A., Gurbuz N., Demircan M.

CYTOKINE, cilt.25, sa.5, ss.204-211, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 5
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/j.cyto.2003.11.001
  • Dergi Adı: CYTOKINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.204-211
  • Anahtar Kelimeler: necrotizing enterocolitis, interferon, intestine, intestinal immune function, cytokine, NITRIC-OXIDE, INFANTS, TRANSLOCATION, PATHOGENESIS, EXPRESSION, HYPOXIA, ILEUM, RAT
  • İnönü Üniversitesi Adresli: Evet

Özet

Cytokines had important role in the pathogenesis of necrotizing enterocolitis (NEC). The aim of this study is to investigate if IFN-alpha has a prophylaxic, effect on experimental NEC development in newborn rat pups. Twenty eight Wistar Albino newborn rat pups were divided into three groups. Control group rats were breast-fed, NEC group and interferon (IFN) group rat pups were hand-fed with premature newborn formula. IFN-alpha was administered subcutaneously at a dose of 50,000 IU/rat/day in IFN group. NEC was induced experimentally by cold stress twice a day in IFN and NEC groups. On the fourth day, the rats were killed, and all the intestine were removed to determine the tissue level of malonaldehyde (MDA) and histologic changes.