Cyclospora cayetanesis is a pathogenic protozoan characterized with prolonged diarrhea in immunocompetent and immunocompromised patients. Despite its ubiqutous distribution, reports on this parasite from Turkey are scarce. Our case is a 28 years old patient, a nurse, who presented to the emergency department in June 2009 with diarrhea, nausea and vomiting during the last week. The stool specimen examination by Kinyoun's acid-fast stain revealed Cyclospora oocysts. Adhesin antigen of Entamoeba histolytica was also positive. The patient was treated with a combination of trimethoprim/sulfamethoxazole and omidazol and she fully recovered. The literature was reviewed and our case proved to be the first report on the coexistance of Cyclospora oocysts and Entamoeba histolytica adhesin antigen in a diarrheic patient. This case underlines the importance of screening for parasites in patients with diarrhea.