Nucleotide-Binding Oligomerization Domain-Containing Protein 2 Variants in Patients with Spontaneous Bacterial Peritonitis

HARPUTLUOĞLU M. M. M., DERTLI R., OTLU B., Demirel U., YENER O., BİLGİÇ Y., ...More

DIGESTIVE DISEASES AND SCIENCES, vol.61, no.6, pp.1545-1552, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 61 Issue: 6
  • Publication Date: 2016
  • Doi Number: 10.1007/s10620-015-4024-y
  • Journal Name: DIGESTIVE DISEASES AND SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1545-1552
  • Keywords: NOD2, Bacterial translocation, Spontaneous bacterial peritonitis, Cirrhosis, TUMOR-NECROSIS-FACTOR, NOD2 GENE VARIANTS, CIRRHOTIC-PATIENTS, SEVERE SEPSIS, SERUM-LEVELS, TURKISH PATIENTS, LIVER-CIRRHOSIS, SEPTIC SHOCK, FACTOR-ALPHA, NOD2/CARD15
  • Inonu University Affiliated: Yes

Abstract

The occurrence of spontaneous bacterial peritonitis (SBP) is significantly increased in carriers of nucleotide-binding oligomerization domain-containing protein 2 (NOD2) variants, suggesting that local immune alterations might be implicated in bacterial translocation (BT).