Nucleotide-Binding Oligomerization Domain-Containing Protein 2 Variants in Patients with Spontaneous Bacterial Peritonitis

HARPUTLUOĞLU, MUHSİN; DERTLI, Ramazan; OTLU, BARIŞ; Demirel, Ulvi; YENER, Ozkan; BİLGİÇ, YILMAZ; ERDOĞAN, MEHMET; ATAYAN, YAHYA; CAGIN, YASİR

doi:10.1007/s10620-015-4024-y

Nucleotide-Binding Oligomerization Domain-Containing Protein 2 Variants in Patients with Spontaneous Bacterial Peritonitis

HARPUTLUOĞLU M. M. M., DERTLI R., OTLU B., Demirel U., YENER O., BİLGİÇ Y., ...Daha Fazla

DIGESTIVE DISEASES AND SCIENCES, cilt.61, sa.6, ss.1545-1552, 2016 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 61 Sayı: 6
Basım Tarihi: 2016
Doi Numarası: 10.1007/s10620-015-4024-y
Dergi Adı: DIGESTIVE DISEASES AND SCIENCES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1545-1552
Anahtar Kelimeler: NOD2, Bacterial translocation, Spontaneous bacterial peritonitis, Cirrhosis, TUMOR-NECROSIS-FACTOR, NOD2 GENE VARIANTS, CIRRHOTIC-PATIENTS, SEVERE SEPSIS, SERUM-LEVELS, TURKISH PATIENTS, LIVER-CIRRHOSIS, SEPTIC SHOCK, FACTOR-ALPHA, NOD2/CARD15
İnönü Üniversitesi Adresli: Evet

Özet

The occurrence of spontaneous bacterial peritonitis (SBP) is significantly increased in carriers of nucleotide-binding oligomerization domain-containing protein 2 (NOD2) variants, suggesting that local immune alterations might be implicated in bacterial translocation (BT).