The Effects of Nitric Oxide on Rat Stomach Injury Induced by Acetylsalicylic Acid

Yagmurca M., UÇAR M., Fadillioglu E., Erdogan H., Ozturk F.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.39, no.1, pp.13-19, 2009 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 1
  • Publication Date: 2009
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.13-19
  • Inonu University Affiliated: Yes

Abstract

Aim: Acetylsalicylic acid (ASA, aspirin), which is one of the most frequently used drugs in the world. causes severe gastric mucosal injury. Nitric oxide (NO) is synthesized from L-arginine by nitric oxide synthase (NOS). NOS can be inhibited by N omega-nitro-L-arginine methyl ester (L-NAME) and stimulated by supplementing the diet with L-arginine (L-Arg). The aim of this study was to investigate the role of NO on gastric mucosal injury induced by ASA.