Antibacterial and antifungal activities of complexes of ruthenium (II)

CETINKAYA B., Ozdemir I., BINBASIOGLU B., DURMAZ R., GUNAL S.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, cilt.49, sa.6, ss.538-540, 1999 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Sayı: 6
  • Basım Tarihi: 1999
  • Dergi Adı: ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.538-540
  • Anahtar Kelimeler: benzimidazole, carbene complexes, imidazoline, ruthenium(II) complexes, antibacterial activity, antifungal activity, in vitro studies tetrahydropyridine, vinylpyridine, ANTITUMOR-ACTIVITY, CATALYTIC PROPERTIES, CARBENE COMPLEXES, CRYSTAL-STRUCTURE, DERIVATIVES, RHODIUM(I), CISPLATIN, BINDING, ANALOG, AGENTS
  • İnönü Üniversitesi Adresli: Evet

Özet

Twenty ruthenium (IT) complexes (1-5) were evaluated for their in vitro antibacterial and antifungal activity against Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Candida albicans and Candida tropicalis. Compounds Id! le, Ih, ii and Ij showed more pronounced antimicrobial activity against Gram-positive bacteria and fungi as compared to the nitrogen donor ruthenium complexes; hydrophobic substituents were significantly mon effective. None of the compounds 1-5 exhibited antimicrobial activity against the Gram-negative strains Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853) with the concentrations ranging between 17.5 and 800 mu g/ml.