The aim of this in-silico study was to compare stress distributions in implants and zirconia frameworks of mandibular and maxillary implant-supported crowns. For comparison, vertical and oblique loading forces were used. Three-dimensional finite-element implant models of a mandibular section of bone (D2) and a maxillary section of bone (D4) with missing second molars and their zirconium-based superstructures were used. Zimmer dental implants of 13 mm in length and 4.7 mm in diameter were modelled. A load of 200 N was applied toward vertical and oblique (30 degrees to the vertical) directions. Maximum and minimum von Mises stress values of the implants and the zirconia framework were calculated. The highest stress value was concentrated in the zirconia framework of the maxillary implant-supported model with the oblique loading force (301.17 MPa). The lowest stress value was concentrated in the mandibular implant-supported model. And the stress values in the maxilla were higher than in the mandible. The maxilla (D4) showed higher stress values than in the mandible (D2), because the trabecular bone is weaker and less resistant to deformation than the cortical bone. Stress values with oblique loading forces were higher than with vertical loading forces. Because of the high Young's modulus of zirconia (low elastic properties), zirconia frameworks showed higher stress values than the implants.