Crocin protects intestine tissue against carbon tetrachloride-mediated oxidative stress in rats

Cosgun B. E., ERDEMLI M. E., GÜL M., GÜL S., Bag H. G., AKSUNGUR Z., ...Daha Fazla

GENERAL PHYSIOLOGY AND BIOPHYSICS, cilt.37, sa.4, ss.399-409, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 4
  • Basım Tarihi: 2018
  • Doi Numarası: 10.4149/gpb_2017057
  • Dergi Adı: GENERAL PHYSIOLOGY AND BIOPHYSICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.399-409
  • Anahtar Kelimeler: CCl4, Crocin, Oxidative stress, MDA, Intestine, HEPATIC STELLATE CELLS, INDUCED HEPATOTOXICITY, CYTOCHROME-P450 ENZYMES, ANTIOXIDANT ACTIVITY, ACTIVE CONSTITUENT, SAFFRON EXTRACT, GENE-EXPRESSION, INDUCED LIVER, TOXICITY, DAMAGE
  • İnönü Üniversitesi Adresli: Evet

Özet

Saffron is used in traditional medicine for its hypolipidemic, anti-inflammatory and anti carcinogenic properties as a natural remedy in treatment of diseases. The objective of the present study was to demonstrate the protective effect of crocin (one of the main ingredients of saffron) on carbon tetrachloride (CCl4) damage in intestinal mucosa. MDA, GSH, SOD, CAT, TAS and TOS levels were measured in experimental animal tissue samples and these were compared with histologic lesions induced by CCl4.CCl4 caused an increase in MDA, SOD, CAT and TOS levels and a significant decrease in GSH and TAS levels in rat intestinal tracts. After crocin treatment, serious improvements were observed in histological lesions and biochemical results in the intestinal tract. In conclusion, crocin inhibited the toxic effects induced by CCl4 in the intestine by its strong antioxidant properties.