Therapeutic potential of coumarin bearing metal complexes: Where are we headed?

Balcioglu S., KARATAŞ M. O., ATEŞ B., ALICI B., ÖZDEMİR İ.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, cilt.30, sa.2, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 30 Sayı: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.bmcl.2019.126805
  • Dergi Adı: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Coumarin derivatives, Metal complexes, Anticancer, Antimicrobial, Biological activity, SILVER(I) COMPLEXES, ANTICANCER ACTIVITY, CRYSTAL-STRUCTURES, PHYSICOCHEMICAL CHARACTERIZATION, ANTIMICROBIAL ACTIVITY, CYTOTOXIC ACTIVITY, DERIVATIVES, 7-HYDROXYCOUMARIN, PSEUDOMONAS, COPPER(II)
  • İnönü Üniversitesi Adresli: Evet

Özet

The successfully application of some metallodrugs such as salvarsan, silver sulfadiazine and cisplatin in modern medicine launched the biological investigation of organometallic and metal-organic complexes. The availability and tunability of various ligands including N-heterocycles, phosphines, N-heterocyclic carbenes present an extended research area to chemists. In recent years, the preparation of the metal complexes of bioactive organic compounds is a new strategy. Coumarin derivatives are one of the classes of compounds used for this purpose, and many complexes of coumarin derivatives were prepared for enhanced biological activity, especially anticancer and antimicrobial. In this paper, we discuss the current situation of this topic.