Effects of strontium ranelate on sutural bone formation: a histological and immunohistochemical study

Karatas O. H., Toy E., Demir A., Toy H., Kozacioglu S.

AUSTRALIAN ORTHODONTIC JOURNAL, vol.32, no.2, pp.139-147, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 2
  • Publication Date: 2016
  • Journal Name: AUSTRALIAN ORTHODONTIC JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.139-147
  • Inonu University Affiliated: Yes

Abstract

Aim: Rapid maxillary expansion is performed to correct a skeletal transverse deficiency of the maxilla, which is a frequently encountered orthodontic anomaly. Strontium ranelate (SrR) is a novel agent that has a dual action, involving anti-resorptive and bone-forming effects. The aim of this study was to evaluate the effects of systemically applied SrR on osteoblastic bone formation after maxillary expansion on the mid-palatal suture of rats using histological and immunohistochemical tests.