Effects of strontium ranelate on sutural bone formation: a histological and immunohistochemical study

Karatas O. H. , Toy E., Demir A., Toy H., Kozacioglu S.

AUSTRALIAN ORTHODONTIC JOURNAL, cilt.32, ss.139-147, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 32 Konu: 2
  • Basım Tarihi: 2016
  • Sayfa Sayıları: ss.139-147


Aim: Rapid maxillary expansion is performed to correct a skeletal transverse deficiency of the maxilla, which is a frequently encountered orthodontic anomaly. Strontium ranelate (SrR) is a novel agent that has a dual action, involving anti-resorptive and bone-forming effects. The aim of this study was to evaluate the effects of systemically applied SrR on osteoblastic bone formation after maxillary expansion on the mid-palatal suture of rats using histological and immunohistochemical tests.