Decreased endothelium-dependent vasodilatation in patients with migraine: a new aspect to vascular pathophysiology of migraine

Yetkin E., Ozisik H., Ozcan C., Aksoy Y., Turhan H.

CORONARY ARTERY DISEASE, vol.17, no.1, pp.29-33, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 1
  • Publication Date: 2006
  • Doi Number: 10.1097/00019501-200602000-00005
  • Journal Name: CORONARY ARTERY DISEASE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.29-33
  • Inonu University Affiliated: Yes

Abstract

Background Migraine is a common neurovascular disorder characterized by attacks of severe headache, autonomic and neurological symptoms. We hypothesized that patients with migraine had abnormal endothelial function. The vascular theory of migraine assumes that the major pathophysiological events that initiate the migraine attack occur in the perivascular nerves of the major cerebral vessels. Accordingly, we aimed to measure endothelium-dependent vasoclilatation in migraineurs by means of flow-mediated dilatation, which reflects endothelium-dependent vasodilatation capacity.