Associations between second-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-alpha and spontaneous preterm delivery in singleton pregnancies

MELEKOĞLU R., YILMAZ E., ÇİFTÇİ O., Kafadar Y. T., Celik E.

JOURNAL OF PERINATAL MEDICINE, vol.47, no.3, pp.304-310, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 3
  • Publication Date: 2019
  • Doi Number: 10.1515/jpm-2018-0297
  • Journal Name: JOURNAL OF PERINATAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.304-310
  • Keywords: ADAMTS, interleukin-6, preterm labor, tumor necrosis factor-alpha, BIRTH, METALLOPROTEINASES, EPIDEMIOLOGY, EXPRESSION, PREDICTION, BIOMARKERS, WOMEN
  • Inonu University Affiliated: Yes

Abstract

Background: We investigated the roles of inflammatory cytokines and the A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family in the etiopathogenesis of spontaneous preterm delivery by comparing the ADAMTS4, ADAMTS5, interleukin (IL)-6, and tumor necrosis factor-alpha (TNF-alpha) levels in second-trimester amniotic fluid between pregnant women with preterm birth and term controls.