Cytotoxic effects of bulk fill composite resins on human dental pulp stem cells

Sisman R., Aksoy A., Yalcin M., Karaoz E.

JOURNAL OF ORAL SCIENCE, cilt.58, ss.299-305, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 58 Konu: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.2334/josnusd.15-0603
  • Sayfa Sayıları: ss.299-305


Five bulk fill composite resins, including SDR, Tetric EvoCeram Bulk Fill (TEC), X-trafil (XTF), Sonic Fill (SF), Filtek Bulk Fill (FBF), were used in this study. Human dental pulp stem cells were cultured in 12-well culture dishes (3 x 104 cells per cm(2)) and stored in an incubator at 37 degrees C and 5% CO2 for 1 day. On days 1, 7, 14, and 21 of co-culture, viable cells were measured using a WST-1 assay. Lower cell viability was observed with XTF and SDR bulk fill composite resins compared to the control group during the WST-1 assay. Although bulk fill composite resins provide advantages in practical applications, they are limited by their cytotoxic properties.