Caffeic acid phenethyl ester (CAPE) attenuates cerebral vasospasm after experimental subarachnoidal haemorrhage by increasing brain nitric oxide levels


ALADAG M., TURKOZ Y. , OZCAN C., SAHNA E., Parlakpinar H. , AKPOLAT N. , ...Daha Fazla

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, cilt.24, ss.9-14, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 24 Konu: 1
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.ijdevneu.2005.12.002
  • Dergi Adı: INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
  • Sayfa Sayıları: ss.9-14

Özet

Background: Cerebral vasospasm, a medical complication of aneurysmal subarachnoid hemorrhage (SAH), is associated with high morbidity and mortality rates, even after the aneurysm has been secured surgically or endovascularly. Evidence accumulated during the last decade suggest that scavenging a vasodilator, nitric oxide (NO), by superoxide anions (O-2(-)), and activating a strong vasoconstructor, protein kinase C (PKC), are the two most important mechanisms in the pathogenesis of vasospasm. Our aim in this study was to determine whether caffeic acid phenethyl ester (CAPE), a non-toxic oxygen free radical scavenger, prevents vasospasm in an experimental rat model of SAH.