Akademik Veri Yönetim Sistemi
Polyhedron, cilt.293, 2026 (SCI-Expanded, Scopus)
A series of N-alkylbenzimidazole derivatives (1a–e) together with their corresponding silver(I) nitrate complexes (2a–e) were successfully synthesized and structurally characterized. Spectroscopic analyses, including FT-IR, 1H NMR and 13C{1H} NMR, combined with elemental analysis, were consistent with the proposed formulations. Structural elucidation was further confirmed by single-crystal X-ray diffraction. In particular, the crystal structure of complex 2c, formulated as bis(N-alkylbenzimidazole)silver(I), reveals a distorted seesaw coordination geometry around the Ag(I) center. The antimicrobial properties of the synthesized compounds were evaluated against Gram-positive and Gram-negative bacterial strains, namely Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli, as well as fungal strains Candida albicans and Candida glabrata. Several compounds displayed notable antibacterial activity, especially toward Gram-negative bacteria, highlighting their potential as antimicrobial candidates. Among them, N-alkyl-5,6-dimethylbenzimidazole derivatives 1a and 1e and silver complexes 2a, 2c, 2d, and 2e exhibited the most pronounced antibacterial effects. Compound 1e and complexes 2b and 2c showed particularly strong antifungal activity. In addition, the silver(I) complexes demonstrated marked cytotoxicity against the tested cancer cell lines, exceeding that of Cisplatin under identical experimental conditions. Beyond their biological properties, these silver(I) complexes were also investigated as catalysts in the three-component A3 coupling reaction between benzaldehyde, amines, and phenylacetylene for the synthesis of propargylamines. The catalytic system afforded complete conversion under mild conditions, producing water as the sole by-product, thus offering an environmentally benign and efficient synthetic protocol.