Effects of pinealectomy and exogenous melatonin on serum leptin levels in male rat

CANPOLAT S., Sandal S. , YILMAZ B. , YASAR A., KUTLU S., BAYDAS G., ...Daha Fazla

EUROPEAN JOURNAL OF PHARMACOLOGY, cilt.428, ss.145-148, 2001 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 428 Konu: 1
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1016/s0014-2999(01)01230-4
  • Sayfa Sayıları: ss.145-148


The effects of pinealectomy and exogenous melatonin (N-acetyl-5-methoxytryptamine) on serum leptin levels were investigated in rats. Exogenous administration of melatonin to intact rats resulted in significant decreases in serum leptin levels (P < 0.05) compared to those of the intact control group. Serum leptin levels were significantly elevated in the pinealectomised rats in comparison to the sham-pinealectomised animals (P < 0.001) and were significantly suppressed by exogenous administration of melatonin compared to those of non-treated pinealectomised rats ( P < 0.001). Hormone concentrations in the melatonin-treated pinealectomised group were found to be similar to those seen in the sham-pinealectomised group. These results suggest that pineal gland has an effect on leptin release. (C) 2001 Elsevier Science B.V. All rights reserved.