Synthesis and antimicrobial activity of novel gold(I) N-heterocyclic carbene complexes

DOGAN O., KALOGLU N., DEMIR S., ÖZDEMİR İ., GÜNAL S., ÖZDEMİR İ.

MONATSHEFTE FUR CHEMIE, vol.144, no.3, pp.313-319, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 144 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.1007/s00706-012-0812-7
  • Journal Name: MONATSHEFTE FUR CHEMIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Page Numbers: pp.313-319
  • Keywords: Gold-NHC complexes, Medicinal inorganic chemistry, Antimicrobial, Benzimidazol-2-ylidene, C-H BONDS, PERMEABILITY TRANSITION, CATALYTIC-ACTIVITY, SILVER COMPLEXES, FACILE SYNTHESIS, LIGAND, CYTOTOXICITY, INHIBITION, AURANOFIN, PALLADIUM
  • Inonu University Affiliated: Yes

Abstract

Benzimidazolium salts and six anionic gold-NHC complexes (NHC = N,N'-dialkylbenzimidazol-2-ylidene) were prepared and characterized. Novel [Au(NHC)(2)]AuCl2-type complexes were prepared in good yields from silver-NHC complexes by treatment with [AuCl(PPh3)], following the commonly used silver carbene transfer route. All compounds were characterized using H-1 and C-13 NMR spectroscopy, elemental analysis, and IR. The gold complexes showed antimicrobial activity against Gram-positive/negative and fungal strains.