Histopathological efficiency of amifostine in radiation-induced heart disease in rats

Gurses, I; Ozeren, M.; Serin, M.; Yucel, N.; Erkal, H.

doi:10.4149/bll_2018_011

Histopathological efficiency of amifostine in radiation-induced heart disease in rats

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Gurses I., Ozeren M., Serin M., Yucel N., Erkal H. S.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, vol.119, no.1, pp.54-59, 2018 (SCI-Expanded)

Publication Type: Article / Article
Volume: 119 Issue: 1
Publication Date: 2018
Doi Number: 10.4149/bll_2018_011
Journal Name: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.54-59
Inonu University Affiliated: No

Abstract

OBJECTIVE: Amifositine is a phosphorylated thiol that holds its radioprotective actions by several indirect mechanisms. The purpose of this study was to evaluate histopathologically whether amifositine administration prior to irradiation would have a long-term protective effect on heart tissue in an experimental rat model.