Akademik Veri Yönetim Sistemi
Journal of MTU, cilt.3, sa.2, ss.53-59, 2024 (Hakemli Dergi)
Background: Cancer is one of the most important health problems causing deaths in Turkey and the world. Nowadays, many
treatment methods such as radiotherapy and chemotherapy are applied in cancer patients. Quinoline and its derivatives, which
belong to heterocyclic compounds, have many biological activities for drug development. Quinoline compounds play a crucial
role in the development of antitumor drugs due to their anticancer activity.
Materials and Methods: In this study, the cytotoxic effects of synthesized seven different quinoline derivatives on lung cancer
(A549) and healthy lung epithelial cell (BEAS2B), liver cancer (Hep 3B), and endothelial cell (HUVEC) were determined.
Different concentrations were applied and IC50 values were calculated at different time courses. The antimicrobial activites of
the compounds were also determined.
Results: The IC50 values of compound 2 on the A549 cell line were determined to be 10.48 μg/mL, 9.738 μg/mL, and 10.14
μg/mL. IC50 values of compound 6 on the same cell line were determined to be 7.307 µg/mL, 9.888 µg/mL, 10.63 µg/mL.
Conclusions: Compounds 2 and 6 had a cytotoxic effect on the BEAS2B cell line. The antimicrobial activity of the compounds
was determined by the minimum inhibition concentration method on different strains of bacteria and yeast. The compounds
showed no antimicrobial activity on bacteria and yeast.
Keywords: Antimicrobial, quinoline-peptide conjugates, cytotoxic