Efficacy of melatonin as protectant against oxidative stress and structural changes in liver tissue in pinealectomized rats
ACTA HISTOCHEMICA, cilt.106, sa.5, ss.331-336, 2004 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 106 Sayı: 5
- Basım Tarihi: 2004
- Doi Numarası: 10.1016/j.acthis.2004.07.006
- Dergi Adı: ACTA HISTOCHEMICA
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.331-336
- Anahtar Kelimeler: melatonin, pinealectomy, glutathione, malondialdehyde, liver, PHARMACOLOGICAL CONCENTRATIONS, ISCHEMIA-REPERFUSION, LIPID-PEROXIDATION, GLUTATHIONE-PEROXIDASE, REACTIVE OXYGEN, REDUCTION, PINEAL, DAMAGE, CISPLATIN, DISEASE
- İnönü Üniversitesi Adresli: Evet
Özet
Previous observations demonstrated that physiological levels of metatonin, the pineal secretory product, are important in protecting against oxidative stress-induced tissue damage. We investigated the effects of pinealectomy and administration of exogenous melatonin on liver tissue in rats. Pinealectomized (Px) and sham-operated (non-Px) rats were used. We evaluated structural changes, reduced glutathione (GSH) levels and matondialdehyde (MDA) levels. Rats were divided into three groups (10 rats in each group): control. (non-Px), Px+vehicle and Px+metatonin (4 mg/kg given daily intraperitoneally for 10 days). Liver GSH levels were significantly tower in Px rats than in the control group. Melatonin administration significantly increased GSH levels (p<0.05). Px caused a significant increase in MDA levels as compared with the control group and metatonin administration to Px rats significantly reduced MDA levels in the liver (p<0.05). Sinusoidal dilatation to a varying degree developed in all Px rats. Severity of mononuclear cell. infiltration and sinusoidal congestion were tower in Px+melatonin group than in the Px group. These findings suggest that a significant increase in oxidative and structural changes occur in rat livers after pinealectomy, which can be diminished by melatonin treatment. (C) 2004 Published by Elsevier GmbH.