Histopathological Features of  the Steatohepatitic Variant of  Hepatocellular Carcinoma  and Its Relationship with Fatty  Liver Disease

Şamdancı, EMİNE

Histopathological Features of the Steatohepatitic Variant of Hepatocellular Carcinoma and Its Relationship with Fatty Liver Disease

in: Hepatocellular Carcinoma - Challenges and Opportunities of a Multidisciplinary Approach, Georgios Tsoulfas, Editor, IntechOpen, London, pp.23-37, 2022

Publication Type: Book Chapter / Chapter Vocational Book
Publication Date: 2022
Publisher: IntechOpen
City: London
Page Numbers: pp.23-37
Editors: Georgios Tsoulfas, Editor
Inonu University Affiliated: Yes

Abstract

Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver in adults. Steatohepatitic HCC (SH-HCC) is a recently described, rarer variant of HCC and is associated with nonalcoholic fatty liver disease (NAFLD). The relationship between fatty liver disease and/or steatohepatitis and SH-HCC is now known. This subtype can be confused with lipid-containing nodules (such as cirrhotic nodules, regenerative nodules, focal nodular hyperplasia) clinically, radiologically and histopathologically. Here, the histopathological features of SH-HCC, its relationship with fatty liver disease and briefly its clinical features will be discussed. In addition, histopathological features of this specific variant, immunohistochemical staining of the tumor and diagnostic difficulties in tru-cut biopsies will also be discussed. Actually, I think this article will raise clinicopathological awareness about this rare variant.