Synthesis, characterization and A3-coupling activity of novel Ag-NHC complexes bearing a 5,6-dimethylbenzimidazole core
Journal of Molecular Structure, vol.1370, 2026 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 1370
- Publication Date: 2026
- Doi Number: 10.1016/j.molstruc.2026.146370
- Journal Name: Journal of Molecular Structure
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica, Compendex, INSPEC
- Keywords: A3-coupling, Ag-NHC, N-heterocyclic carbene (NHCS), Propargyl amine
- Inonu University Affiliated: Yes
Abstract
The A3-coupling reaction, involving the one-pot three-component condensation of an aldehyde, an alkyne, and an amine to form propargyl amines, has emerged as a powerful synthetic tool in modern organic chemistry. Among various metal catalysts, silver(I)-based systems, especially those supported by N-heterocyclic carbenes (NHCs), have demonstrated excellent catalytic performance under mild and sustainable conditions. Ag(I)-NHC complexes offer enhanced stability, tunable steric and electronic properties, and high catalytic efficiency, enabling efficient C-H activation and bond formation in A3-coupling processes. Recent study, we prepared five new silver NHC complexes and the structures of the newly synthesized complexes were confirmed by NMR (¹H, ¹³C), FT-IR and HR-MS analysis. All synthesized complexes used catalyst for A3-coupling reactions. The catalytic studies were carried out in air using water as the solvent. In contrast to similar studies, the use of water as the solvent introduced novelty to the subject.