Synthesis, antimicrobial properties, and theoretical analysis of benzimidazole-2-ylidene silver(I) complexes


DEMİR DÜŞÜNCELİ S. , Ayaz D., ÜSTÜN E., GÜNAL S. , ÖZDEMİR N., DİNÇER M., ...More

JOURNAL OF COORDINATION CHEMISTRY, vol.73, no.13, pp.1967-1986, 2020 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 73 Issue: 13
  • Publication Date: 2020
  • Doi Number: 10.1080/00958972.2020.1812587
  • Title of Journal : JOURNAL OF COORDINATION CHEMISTRY
  • Page Numbers: pp.1967-1986
  • Keywords: Antimicrobial activity, benzimidazolium salts, N-heterocyclic carbene, silver NHC complexes, HETEROCYCLIC CARBENE COMPLEXES, CRYSTAL-STRUCTURES, STRUCTURAL-CHARACTERIZATION, REACTIVITY DESCRIPTORS, BIOLOGICAL-ACTIVITY, AG(I) COMPLEXES, METAL-COMPLEXES, IN-VITRO, LIGANDS, POLYMER

Abstract

A series of symmetrical and nonsymmetricalN,N-disubstituted benzimidazolium salts were synthesized asN-heterocyclic carbene precursors. These salts were treated with Ag2O to afford their corresponding mononuclear Ag(I)-NHC complexes. These compounds were characterized by spectroscopy techniques and analyzed by DFT/TDDFT and docking methods. Also, the structures of2aand2ewere determined by single-crystal X-ray crystallography. These new Ag-NHC complexes were screened for their antibacterial activities against Gram-positive, Gram-negative bacteria, fungi, and nosocomial agents.