Paraoxonase-1 gene in patients with chronic obstructive pulmonary disease investigation Q192R and L55M polymorphisms


GÜRBÜZ Ş., Yildiz M., KARA M., KARGÜN K., GÜRGER M., ATEŞÇELİK M., ...More

WORLD JOURNAL OF EMERGENCY MEDICINE, vol.6, no.3, pp.201-206, 2015 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 3
  • Publication Date: 2015
  • Doi Number: 10.5847/wjem.j.1920-8642.2015.03.007
  • Journal Name: WORLD JOURNAL OF EMERGENCY MEDICINE
  • Journal Indexes: Science Citation Index Expanded, Emerging Sources Citation Index
  • Page Numbers: pp.201-206

Abstract

BACKGROUND: The effect of increased oxidative stress on the development of chronic obstructive pulmonary disease (COPD) is well known. One of the antioxidative systems against oxidative stress in human body is paraoxonase (PON) enzyme that protects low density lipoproteins (LDL) against oxidation. This study aimed to explore the polymorphisms on PON1, Q192R, L55M genes of patients with COPD.