Neuroprotective effects of the new Na channel blocker rs100642 in global ischemic brain injury
ARCHIVES OF MEDICAL SCIENCE, cilt.15, sa.2, ss.467-474, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 15 Sayı: 2
- Basım Tarihi: 2019
- Doi Numarası: 10.5114/aoms.2017.72550
- Dergi Adı: ARCHIVES OF MEDICAL SCIENCE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.467-474
- Anahtar Kelimeler: brain injury, global cerebral ischemia, sodium channels, neuroprotection, GLUTATHIONE-PEROXIDASE-ACTIVITY, CEREBRAL-ISCHEMIA, CASPASE ACTIVATION, OXIDATIVE STRESS, CELL-DEATH, MODEL, MECHANISMS, APOPTOSIS, OXYGEN, REPERFUSION
- İnönü Üniversitesi Adresli: Evet
Özet
Introduction: RS100642, a mexiletine analogue, is a novel sodium channel blocker with neuroprotective and antioxidant activities. The protectivity of RS100642, which has been shown against focal cerebral ischemia, was investigated in global cerebral ischemia in this study.