Neuroprotective effects of the new Na channel blocker rs100642 in global ischemic brain injury

KAMIŞLI S., BASARAN C., BATÇIOĞLU K., ÖZTANIR M. N., GÜL M., SATILMIŞ B., ...Daha Fazla

ARCHIVES OF MEDICAL SCIENCE, cilt.15, sa.2, ss.467-474, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 2
  • Basım Tarihi: 2019
  • Doi Numarası: 10.5114/aoms.2017.72550
  • Dergi Adı: ARCHIVES OF MEDICAL SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.467-474
  • Anahtar Kelimeler: brain injury, global cerebral ischemia, sodium channels, neuroprotection, GLUTATHIONE-PEROXIDASE-ACTIVITY, CEREBRAL-ISCHEMIA, CASPASE ACTIVATION, OXIDATIVE STRESS, CELL-DEATH, MODEL, MECHANISMS, APOPTOSIS, OXYGEN, REPERFUSION
  • İnönü Üniversitesi Adresli: Evet

Özet

Introduction: RS100642, a mexiletine analogue, is a novel sodium channel blocker with neuroprotective and antioxidant activities. The protectivity of RS100642, which has been shown against focal cerebral ischemia, was investigated in global cerebral ischemia in this study.