Neuroprotective effects of the new Na channel blocker rs100642 in global ischemic brain injury

KAMIŞLI S., BASARAN C., BATÇIOĞLU K., ÖZTANIR M. N., GÜL M., SATILMIŞ B., ...More

ARCHIVES OF MEDICAL SCIENCE, vol.15, no.2, pp.467-474, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.5114/aoms.2017.72550
  • Journal Name: ARCHIVES OF MEDICAL SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.467-474
  • Keywords: brain injury, global cerebral ischemia, sodium channels, neuroprotection, GLUTATHIONE-PEROXIDASE-ACTIVITY, CEREBRAL-ISCHEMIA, CASPASE ACTIVATION, OXIDATIVE STRESS, CELL-DEATH, MODEL, MECHANISMS, APOPTOSIS, OXYGEN, REPERFUSION
  • Inonu University Affiliated: Yes

Abstract

Introduction: RS100642, a mexiletine analogue, is a novel sodium channel blocker with neuroprotective and antioxidant activities. The protectivity of RS100642, which has been shown against focal cerebral ischemia, was investigated in global cerebral ischemia in this study.