Akademik Veri Yönetim Sistemi
Int J Cancer Res Mol Mech, cilt.2, sa.1, ss.1-4, 2016 (Hakemli Dergi)
Abstract
Background: Locally advanced rectal cancer is defined as a rectal mass that cannot be resected without a high probability of leaving residual
disease at the tumor site. While the standard treatment for locally advanced rectal cancer is chemoradiotherapy followed by surgery, this study
reports a locally invasive rectal adenocarcinoma patient who achieved complete pathological and clinical remission after receiving a combination
of metabolically supported chemotherapy (MSCT), radiotherapy (RT) and hyperthermia (HT).
Case presentation: An 81-year-old female underwent a rectosigmoidoscopy at a referring hospital following a complaint of bloody stools for
a period of 20 days. The rectosigmoidoscopy revealed an ulcerated tumor beginning at the level of the anal sphincter. A pathological examination
of biopsy material revealed moderately differentiated invasive adenocarcinoma and the patient received a diagnosis of stage III (T3N2M0) lowlying rectal cancer. When further follow-up revealed colonic obstruction, the patient was recommended an abdominoperineal resection (APR) and
was referred after refusing surgical treatment. The patient received a metabolically supported combination of oxaliplatin, 5-florouracil (5-FU) and
calcium folinate (FOLFOX6) concomitant to RT and local HT and, ultimately, never underwent surgery. 27 months since her disease-free PET-CT
scan, the patient remains with no sign of disease recurrence.
Conclusion: According to the findings of the present study, the non-surgical treatment and achievement of complete clinical and pathological
remission of locally advanced rectal adenocarcinoma may be possible by means of a combination of MSCT, RT and HT.
Keywords: Pathological complete response; Locally advanced rectal cancer; Metabolically supported chemotherapy; Hyperthermia