Protective Effect of Quercetin Against Oxidative Stressinduced Toxicity Associated With Doxorubicin and Cyclophosphamide in Rat Kidney and Liver Tissue

KOCAHAN S., DOĞAN Z., Erdemli E., TAŞKIN E.

IRANIAN JOURNAL OF KIDNEY DISEASES, vol.11, no.2, pp.124-131, 2017 (SCI-Expanded, Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 2
  • Publication Date: 2017
  • Journal Name: IRANIAN JOURNAL OF KIDNEY DISEASES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.124-131
  • Keywords: cyclophosphamide, doxorubicin, quercetin, oxidative stress, liver, kidney, LIPID-PEROXIDATION, DNA-DAMAGE, STRESS, CARDIOTOXICITY, INHIBITION, APOPTOSIS, CELLS, HEART
  • Inonu University Affiliated: No

Abstract

Introduction. Doxorubicin and cyclophosphamide are widely used anticancer drugs with substantial toxicity in noncancerous tissue resulting from oxidative damage. Quercetin is a potent antioxidant compound. We hypothesized that quercetin administration would ameliorate the toxic effects of doxorubicin and cyclophosphamide prior to pregnancy.