Protective Effect of Quercetin Against Oxidative Stressinduced Toxicity Associated With Doxorubicin and Cyclophosphamide in Rat Kidney and Liver Tissue

KOCAHAN, SAYAD; DOĞAN, ZÜMRÜT; Erdemli, MEHMET; TAŞKIN, EYLEM

Protective Effect of Quercetin Against Oxidative Stressinduced Toxicity Associated With Doxorubicin and Cyclophosphamide in Rat Kidney and Liver Tissue

Atıf İçin Kopyala

KOCAHAN S., DOĞAN Z., Erdemli E. , TAŞKIN E.

IRANIAN JOURNAL OF KIDNEY DISEASES, cilt.11, ss.124-131, 2017 (SCI İndekslerine Giren Dergi)

Cilt numarası: 11 Konu: 2
Basım Tarihi: 2017
Dergi Adı: IRANIAN JOURNAL OF KIDNEY DISEASES
Sayfa Sayıları: ss.124-131

Özet

Introduction. Doxorubicin and cyclophosphamide are widely used anticancer drugs with substantial toxicity in noncancerous tissue resulting from oxidative damage. Quercetin is a potent antioxidant compound. We hypothesized that quercetin administration would ameliorate the toxic effects of doxorubicin and cyclophosphamide prior to pregnancy.