Protective Effect of Quercetin Against Oxidative Stressinduced Toxicity Associated With Doxorubicin and Cyclophosphamide in Rat Kidney and Liver Tissue
IRANIAN JOURNAL OF KIDNEY DISEASES, cilt.11, sa.2, ss.124-131, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 11 Sayı: 2
- Basım Tarihi: 2017
- Dergi Adı: IRANIAN JOURNAL OF KIDNEY DISEASES
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.124-131
- Anahtar Kelimeler: cyclophosphamide, doxorubicin, quercetin, oxidative stress, liver, kidney, LIPID-PEROXIDATION, DNA-DAMAGE, STRESS, CARDIOTOXICITY, INHIBITION, APOPTOSIS, CELLS, HEART
- İnönü Üniversitesi Adresli: Hayır
Özet
Introduction. Doxorubicin and cyclophosphamide are widely used anticancer drugs with substantial toxicity in noncancerous tissue resulting from oxidative damage. Quercetin is a potent antioxidant compound. We hypothesized that quercetin administration would ameliorate the toxic effects of doxorubicin and cyclophosphamide prior to pregnancy.